The new Research Training Group 2413 “SynAGE” at the Otto von Guericke University, the Leibniz Institute for Neurobiology (LIN) and the German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany offers 13 PhD positions for talented, skilled, and highly motivated students of the Life Sciences starting from January 1st, 2019.
RTG 2413 is funded by the DFG (Deutsche Forschungsgemeinschaft) with funds from the federal republic of Germany.
The innovative research program of RTG2413 SynAGE deals with the idea that cognitive decline in normal aging results from subtle synaptic alterations that impart an imbalance between stability and plastic properties of spine synapses and that is qualitatively different from neurodegeneration. Despite the high burden for each individual and the society as a whole the molecular, cellular, and behavioral underpinnings of the ageing process itself and cognitive decline are barely understood. We concentrate on synaptic dysbalances involving these four core principles:
- altered synaptic proteostasis (Dieterich Lab, Stork Lab, Kreutz Lab),
- dysfunctions of the immune system (Kreutz Lab, Dunay Lab),
- altered functionality of the multipartite synapse (Dityatev Lab, Schreiber Lab, Gundelfinger Lab, Seidenbecher Lab, Dieterich Lab) and
- changes in neuromodulation (Leßmann Lab, Stork Lab, Düzel Lab, Ullsperger Lab)
SynAGE will address these four transversal themes in a joint effort by a team of molecular/cellular and systems neurobiologists to eventually break ground for innovative intervention strategies.