Christian Mawrin

Head of the Institute of Neuropathology, Medical Faculty at the Otto von Guericke University Magdeburg

The central goal of our research is to develop a better understanding of meningioma biology, including molecular signatures, which characterize high grade and brain invasive meningiomas. With respect to migration and invasion a major focus is currently laid on the role of small GTPases of the Rho-family and on integrins, which are relevant players in tumor cell motility, integrins being at the same time an interesting therapeutic target to minimize brain invasion. A second focus is laid on the pro-mitogenic axis from receptor tyrosine kinases (RTKs) via PI3K, Akt and mTORC1/2. Small kinase inhibitors are tested for their potential clinical benefit in intracranial meningioma mouse models.

Keywords: meningioma – mouse model – targeted therapy – migration – NF2

Location: OVGU (FME)

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