Jürgen Goldschmidt

Senior Research Scientist at the Department of Systems Physiology of Learning at the Leibniz Institute for Neurobiology Magdeburg

My research focusses on studying brain metabolism and brain activation patterns in awake unrestrained rodents. Based on previous experiences with 14C-2-deoxyglucose autoradiography different new approaches for imaging brain activation patterns have been developed in the lab. The lipophilic chelate complex thallium diethyldithiocarbamate (TlDDC) has been introduced for imaging cerebral K+-metabolism and neuronal activity. Protocols have been developed for in vivo single-photon emission computed tomography (SPECT) imaging of the spatial patterns of the average cerebral blood flow integrated over several minutes of awake unrestrained behavior.

Keywords: cerebral metabolism – imaging – brain activation patterns – SPECT – histochemistry – neurodegeneration

Location: LIN

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